Hyperpigmentation of palms - A clue to B12 deficiency

Reversible cutaneous hyperpigmentation in vitamin B12 deficiency.

Received: 08.02.2013; Revised: 01.04.2013; Accepted: 26.04.2013 A 6 6 ye a r o l d m a l e p r e s e n t e d w i t h g e n e r a l i s e d we a k n e s s , hyperpigmentation of knuckles and decreased appetite since two months. Clinical examination revealed a bald tongue, pallor, glossitis, stomatitis, k n u c k l e p i g m e n t a t i o n , p a l m pigmentation, pigmentation of the sole (Figure...

Generalised hyperpigmentation in vitamin B12 deficiency.

In developing countries like India, nutritional deficiencies are prevalent and hyperpigmentation due to protein energy malnutrition, zinc deficiency and pellagra are common. Indian women, especially vegetarian are prone to vitamin B12 deficiency. Vitamin B12 deficiency can present as anaemia, neurological defect, gastrointestinal symptoms or dementia. Hyperpigmentation as the first presentation...

Reversible Facial Hyperpigmentation Associated With Vitamin B12 Deficiency.

Vitamin B12 (cobalamin) deficiency is common in developing countries. Its dermatologic manifestations include hair and nail changes and glossitis. Cases of generalized hyperpigmentation associated with vitamin B12 deficiency have rarely been reported. Localized hyperpigmentation is less frequently described, affecting palms, soles, and flexural areas. We report a rare case of reversible melasma...

Skin hyperpigmentation and increased angiogenesis secondary to vitamin B12 deficiency in a young vegetarian woman.

Recreational Nitrous Oxide Abuse-Induced Vitamin B12 Deficiency in a Patient Presenting with Hyperpigmentation of the Skin

Vitamin B12 deficiency causes skin hyperpigmentation, subacute combined degeneration of the spinal cord, and megaloblastic anemia. Although vitamin B12 deficiency rarely occurs in well-nourished, healthy, young people, nitrous oxide (N2O) intoxication is an important cause of vitamin B12 deficiency in this cohort. N2O, a colorless gas used as an anesthetic since the late 19th century because of...